siRNADelivery相关论文
An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safet
Gene therapy using small interfering RNA (siRNA) is emerging as a novel therapeutic approach to treat various diseases.H......
Gene therapy based on small interfering RNA (siRNA) has emerged as a promising therapeutic approach for the treatment of......
Packing nucleic acids inside a single molecule of networked cationic polymer of tunable size,degrada
Although the chemical mechanisms for constructing efficient delivery carriers of nucleic acids are existing in nature as......
The emerging treatment of RNA interference (RNAi) has drawn considerable attention from cancer researchers over the past......
For successful RNAi-based cancer therapy,a safe and efficient siRNA delivery system is needed[1].Here,we report a novel ......
Precisely regulated nanoarchitecture comprised of gold nanotemplate and unimer polyion complex for s
RNA interference (RNM) mediated by small interfering RNA (siRNA) has attracted wide international attention for treatmen......
Target-specific delivery of Bcl2 siRNA by bioreducible crosslinked hyaluronic acid/ calcium phosphat
Low toxicity and high transfection efficiency are among the most important preconditions for selecting a non-viral gene ......
Small interfering RNA (siRNA) delivery is considered as a promising tool for tumor ablation.Among so many carriers used ......
With the discovery of RNA interference technology,small interference RNA (siRNA) has become a very important tool for ca......
Early endosome pH-sensitive nanomicelles for high-efficiency siRNA delivery in vitro and vivo:An ins
Beside cellular up-taking,the extremely low-efficient cytosolic release of the internalized siRNA has been concerned for......
Natural cellular membrane-based biomimetic nanoparticles have gained widespread attention owing to their cell surface mi......
Polycations are widely used as chemical vectors to deliver nucleic acids.However,their clinical applications are limited......
Bioreducible cross-linked hyaluronic acid/calcium phosphate hybrid nanoparticles for specific delive
Stimuli-responsive delivery systems have been increasingly ultilized to promote physiological specificity and on-demand ......
Polyethylene-polyglutamine as a gene carrier delivering MDR1 siRNA to A549/DDP cells for reversal of
A major problem in cancer chemotherapy is the development of multidrug resistance(MDR)by tumour cells.In recent years,RN......
For RNA interference (RNAi), developing efficient siRNA delivery vehicles has become a major task.In this study, a serie......
Self-assembly nanoparticles based on c(RGDfk) peptide for the delivery of siRNA targeting VEGFR2 gen
The clinical application of small interference RNA (siRNA) has been restricted by poor intracellular uptake, low serum s......
Due to their biodegradable character,polyesters such as polycaprolactone(PCL),poly(D,L-lactide)(PDLLA),and polylacti......
Development of RNA aptamers that bind hepato-specific asialoglycoprotein receptor and enter hepatocy
The development of reagents with high affinity and specificity to thehepatocytes is of great significance to the early-s......
Acid-activatible micelleplex delivering siRNA-PD-L1 for improved cancer immunotherapy of CDK4/6 inhi
Cyclin-dependent kinases 4 and 6 inhibitors(CDK4/6i)have been demonstrated to trigger antitumor immunity for tumor regre......
